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Rayleigh - A face - to - face view of Poly Prion zinc granules

Rayleigh - A face - to - face view of Poly Prion zinc granules

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-05-28
  • Views:0

(Summary description)


L-carinosin zinc complex (L-CAZ), also known as Polaprezinc, is the first oral medication with zinc as its main ingredient, clinically used to treat stomach ulcers. Due to the polymerization characteristic of L-CAZ, it can be slowly dissociated in gastric juice and function for a long time, and adhere to the ulcer focus specifically, releasing L-carnosine and zinc to treat ulcers. The clinical application effect of polyprezon was good and no serious adverse reactions occurred. At the same time, the growth of Hp was significantly inhibited by polyprazine.

Why is the combination of zinc and L-carnosine optimal?

1. L-carnosine is one of the most ideal ligands for zinc

L-carnosine is composed of -alanine (Ala) and L-histidine (His). Table 1 shows the main chemical forms of zinc in human plasma, clearly indicating the importance of histidine in zinc complexation. Therefore, L-carnosine is considered as one of the most ideal ligand for zinc, which can be used in the medical field.

Table 1 Main chemical forms and distribution of trace element complexes in human model plasma



2. L-carnosine is the ideal transporter of zinc

We studied the therapeutic effect of polypretidine and other zinc compounds on gastric ulcer, and the results showed that the anti-ulcer effect of polypretidine was significantly better than that of cimetidine at the same dose (Table 2). Cimetidine is a recognized drug for gastric ulcer.

Table 2 Inhibitory effects of zinc compound on gastric ulcer stress in rats after immersion in water



How does polyprion zinc play a role?

Poly pury zinc to specific adhesion of ulcer lesions from zinc and form new chemical bonds between human body composition, the human body composition/other proteins (albumin) in the ulcer site seepage, and has the functional groups such as sulphur or imidazole, forming complexes of zinc ions firmly with the L - carnosine and zinc is still in a state of combination, so the ulcer local play a role of exogenous protection. During complex formation, a small amount of carnosinin is released in the ulcer and replaces the human body components, playing a role of local anti-inflammation and anti-oxidation, while zinc will accumulate in the ulcer and form a larger zinc complex, capturing human components and entering the ulcer to relieve inflammation.

Studies have shown that gastric mucosal protective effect of zinc pury and do not rely on dmPGE ₂, at the same time also has anti-inflammatory antioxidant, promoting wound healing, membrane stability, cell protection and promote mucosal defense mechanism, and so on, for all kinds of experimental ulcer model has very good therapeutic effect, so can act as endogenous repair function.

Can Polypramide inhibit Hp growth? Is it toxic?

The eradication rate of Hp was significantly improved by Rayleixen (Polyprazine)

In recent years, the eradication of Helicobacter pylori (Hp) has attracted much attention. Drugs that can improve the eradication rate of Hp are of great significance. Rui was born (poly pury zinc particles) Ⅳ phase of clinical trial results show that the red was born combined triple therapy of Hp eradicate rate is significantly higher than that of conventional triple therapy, Hp eradicate rate increased by 19.7% (figure 1), and no difference between the incidence of adverse reactions.



  

Figure 1 Helicobacter pylori eradication rates in ITT and PP populations

Arm A: Relicin 75mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice A day; Arm B: Relicin 150mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice a day; Arm C: Omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500m, oral twice a day.

Many clinical studies have shown significant improvement in symptoms and compliance in patients treated with polypramide for ulcers. The cure rate of endoscopic ulcer was 27.3% and 64.5% after 4 and 8 weeks of treatment, respectively. After 4 weeks and 8 weeks, the "significant improvement" rate was 61.3% and 72.0%, respectively. No adverse reactions were reported in 691 clinical trials, indicating that polypramide is safe and non-toxic.

Can polyprede zinc take for a long time? Is there any accumulation?

Using 14C to mark the carnosine in polypramide, urine containing 4.1%, feces containing 13.3%, 38% in the form of gas, it can be seen that carnosine is mainly discharged from the body in the form of gas;

65Zn was used to mark the zinc ions in poly Prion zinc, urine containing 0.3%, indicating that zinc basically does not pass the excretion of the kidney, for renal insufficiency can also take normally, stool containing 85.0%, absorbed about 11%, which indicates that zinc ions in the body is safe without accumulation, can be taken for a long time.

Have discussions

Helicobacter pylori (Hp) bacteria in the body contains a lot of urea enzyme activity, it is an important pathogenic factors of Hp infection, a large number of studies have shown that poly pury zinc Hp eradication of pharmacologic

Rayleigh - A face - to - face view of Poly Prion zinc granules

(Summary description)


L-carinosin zinc complex (L-CAZ), also known as Polaprezinc, is the first oral medication with zinc as its main ingredient, clinically used to treat stomach ulcers. Due to the polymerization characteristic of L-CAZ, it can be slowly dissociated in gastric juice and function for a long time, and adhere to the ulcer focus specifically, releasing L-carnosine and zinc to treat ulcers. The clinical application effect of polyprezon was good and no serious adverse reactions occurred. At the same time, the growth of Hp was significantly inhibited by polyprazine.

Why is the combination of zinc and L-carnosine optimal?

1. L-carnosine is one of the most ideal ligands for zinc

L-carnosine is composed of -alanine (Ala) and L-histidine (His). Table 1 shows the main chemical forms of zinc in human plasma, clearly indicating the importance of histidine in zinc complexation. Therefore, L-carnosine is considered as one of the most ideal ligand for zinc, which can be used in the medical field.

Table 1 Main chemical forms and distribution of trace element complexes in human model plasma



2. L-carnosine is the ideal transporter of zinc

We studied the therapeutic effect of polypretidine and other zinc compounds on gastric ulcer, and the results showed that the anti-ulcer effect of polypretidine was significantly better than that of cimetidine at the same dose (Table 2). Cimetidine is a recognized drug for gastric ulcer.

Table 2 Inhibitory effects of zinc compound on gastric ulcer stress in rats after immersion in water



How does polyprion zinc play a role?

Poly pury zinc to specific adhesion of ulcer lesions from zinc and form new chemical bonds between human body composition, the human body composition/other proteins (albumin) in the ulcer site seepage, and has the functional groups such as sulphur or imidazole, forming complexes of zinc ions firmly with the L - carnosine and zinc is still in a state of combination, so the ulcer local play a role of exogenous protection. During complex formation, a small amount of carnosinin is released in the ulcer and replaces the human body components, playing a role of local anti-inflammation and anti-oxidation, while zinc will accumulate in the ulcer and form a larger zinc complex, capturing human components and entering the ulcer to relieve inflammation.

Studies have shown that gastric mucosal protective effect of zinc pury and do not rely on dmPGE ₂, at the same time also has anti-inflammatory antioxidant, promoting wound healing, membrane stability, cell protection and promote mucosal defense mechanism, and so on, for all kinds of experimental ulcer model has very good therapeutic effect, so can act as endogenous repair function.

Can Polypramide inhibit Hp growth? Is it toxic?

The eradication rate of Hp was significantly improved by Rayleixen (Polyprazine)

In recent years, the eradication of Helicobacter pylori (Hp) has attracted much attention. Drugs that can improve the eradication rate of Hp are of great significance. Rui was born (poly pury zinc particles) Ⅳ phase of clinical trial results show that the red was born combined triple therapy of Hp eradicate rate is significantly higher than that of conventional triple therapy, Hp eradicate rate increased by 19.7% (figure 1), and no difference between the incidence of adverse reactions.



  

Figure 1 Helicobacter pylori eradication rates in ITT and PP populations

Arm A: Relicin 75mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice A day; Arm B: Relicin 150mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice a day; Arm C: Omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500m, oral twice a day.

Many clinical studies have shown significant improvement in symptoms and compliance in patients treated with polypramide for ulcers. The cure rate of endoscopic ulcer was 27.3% and 64.5% after 4 and 8 weeks of treatment, respectively. After 4 weeks and 8 weeks, the "significant improvement" rate was 61.3% and 72.0%, respectively. No adverse reactions were reported in 691 clinical trials, indicating that polypramide is safe and non-toxic.

Can polyprede zinc take for a long time? Is there any accumulation?

Using 14C to mark the carnosine in polypramide, urine containing 4.1%, feces containing 13.3%, 38% in the form of gas, it can be seen that carnosine is mainly discharged from the body in the form of gas;

65Zn was used to mark the zinc ions in poly Prion zinc, urine containing 0.3%, indicating that zinc basically does not pass the excretion of the kidney, for renal insufficiency can also take normally, stool containing 85.0%, absorbed about 11%, which indicates that zinc ions in the body is safe without accumulation, can be taken for a long time.

Have discussions

Helicobacter pylori (Hp) bacteria in the body contains a lot of urea enzyme activity, it is an important pathogenic factors of Hp infection, a large number of studies have shown that poly pury zinc Hp eradication of pharmacologic

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-05-28
  • Views:0
Information

L-carinosin zinc complex (L-CAZ), also known as Polaprezinc, is the first oral medication with zinc as its main ingredient, clinically used to treat stomach ulcers. Due to the polymerization characteristic of L-CAZ, it can be slowly dissociated in gastric juice and function for a long time, and adhere to the ulcer focus specifically, releasing L-carnosine and zinc to treat ulcers. The clinical application effect of polyprezon was good and no serious adverse reactions occurred. At the same time, the growth of Hp was significantly inhibited by polyprazine.

Why is the combination of zinc and L-carnosine optimal?

1. L-carnosine is one of the most ideal ligands for zinc

L-carnosine is composed of -alanine (Ala) and L-histidine (His). Table 1 shows the main chemical forms of zinc in human plasma, clearly indicating the importance of histidine in zinc complexation. Therefore, L-carnosine is considered as one of the most ideal ligand for zinc, which can be used in the medical field.

Table 1 Main chemical forms and distribution of trace element complexes in human model plasma

2. L-carnosine is the ideal transporter of zinc

We studied the therapeutic effect of polypretidine and other zinc compounds on gastric ulcer, and the results showed that the anti-ulcer effect of polypretidine was significantly better than that of cimetidine at the same dose (Table 2). Cimetidine is a recognized drug for gastric ulcer.

Table 2 Inhibitory effects of zinc compound on gastric ulcer stress in rats after immersion in water

How does polyprion zinc play a role?

Poly pury zinc to specific adhesion of ulcer lesions from zinc and form new chemical bonds between human body composition, the human body composition/other proteins (albumin) in the ulcer site seepage, and has the functional groups such as sulphur or imidazole, forming complexes of zinc ions firmly with the L - carnosine and zinc is still in a state of combination, so the ulcer local play a role of exogenous protection. During complex formation, a small amount of carnosinin is released in the ulcer and replaces the human body components, playing a role of local anti-inflammation and anti-oxidation, while zinc will accumulate in the ulcer and form a larger zinc complex, capturing human components and entering the ulcer to relieve inflammation.

Studies have shown that gastric mucosal protective effect of zinc pury and do not rely on dmPGE ₂, at the same time also has anti-inflammatory antioxidant, promoting wound healing, membrane stability, cell protection and promote mucosal defense mechanism, and so on, for all kinds of experimental ulcer model has very good therapeutic effect, so can act as endogenous repair function.

Can Polypramide inhibit Hp growth? Is it toxic?

The eradication rate of Hp was significantly improved by Rayleixen (Polyprazine)

In recent years, the eradication of Helicobacter pylori (Hp) has attracted much attention. Drugs that can improve the eradication rate of Hp are of great significance. Rui was born (poly pury zinc particles) Ⅳ phase of clinical trial results show that the red was born combined triple therapy of Hp eradicate rate is significantly higher than that of conventional triple therapy, Hp eradicate rate increased by 19.7% (figure 1), and no difference between the incidence of adverse reactions.

  

Figure 1 Helicobacter pylori eradication rates in ITT and PP populations

Arm A: Relicin 75mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice A day; Arm B: Relicin 150mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice a day; Arm C: Omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500m, oral twice a day.

Many clinical studies have shown significant improvement in symptoms and compliance in patients treated with polypramide for ulcers. The cure rate of endoscopic ulcer was 27.3% and 64.5% after 4 and 8 weeks of treatment, respectively. After 4 weeks and 8 weeks, the "significant improvement" rate was 61.3% and 72.0%, respectively. No adverse reactions were reported in 691 clinical trials, indicating that polypramide is safe and non-toxic.

Can polyprede zinc take for a long time? Is there any accumulation?

Using 14C to mark the carnosine in polypramide, urine containing 4.1%, feces containing 13.3%, 38% in the form of gas, it can be seen that carnosine is mainly discharged from the body in the form of gas;

65Zn was used to mark the zinc ions in poly Prion zinc, urine containing 0.3%, indicating that zinc basically does not pass the excretion of the kidney, for renal insufficiency can also take normally, stool containing 85.0%, absorbed about 11%, which indicates that zinc ions in the body is safe without accumulation, can be taken for a long time.

Have discussions

Helicobacter pylori (Hp) bacteria in the body contains a lot of urea enzyme activity, it is an important pathogenic factors of Hp infection, a large number of studies have shown that poly pury zinc Hp eradication of pharmacological activities mainly comes from zinc ions, zinc instead of nickel ions on urease activity sites, interfere with the metal ions complexation and inhibit urease activity, thereby inhibit the growth of Hp.

Broad Great Ruirishen - Jupreui zinc particles can accurately attack urease, an important pathogenic factor of Hp infection, thus significantly improving the eradication rate of Hp. Its unique mechanism of action, do not rely on dmPGE ₂, is a non-toxic, no accumulation of safe and effective mucosal protective agent.

 

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