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Leading experts in the field of digestive endoscopy gathered together to explore the problem of artificial ulcer after ESD operation

Leading experts in the field of digestive endoscopy gathered together to explore the problem of artificial ulcer after ESD operation

  • Categories:The news
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  • Time of issue:2019-08-01
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(Summary description)Research plan of the conference on clinical test, ESD postoperative artificial ulcer related question has carried on the thorough discussion, in order to further verify the red was born with esso beauty pull azole therapy ESD postoperative efficacy and safety of the ulcer of multi-center clinical research project start work laid a solid foundation, at the same time, also further promote the population of our country the ESD postoperative gastric ulcer drug treatment, the optimal scheme and the course of exploration.

Leading experts in the field of digestive endoscopy gathered together to explore the problem of artificial ulcer after ESD operation

(Summary description)Research plan of the conference on clinical test, ESD postoperative artificial ulcer related question has carried on the thorough discussion, in order to further verify the red was born with esso beauty pull azole therapy ESD postoperative efficacy and safety of the ulcer of multi-center clinical research project start work laid a solid foundation, at the same time, also further promote the population of our country the ESD postoperative gastric ulcer drug treatment, the optimal scheme and the course of exploration.

  • Categories:The news
  • Author:
  • Origin:
  • Time of issue:2019-08-01
  • Views:0
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-- Highlights of the Rayleigh Clinical Protocol Discussion Meeting

On July 21, 2019, by the Beijing tsinghua chang gung memorial hospital affiliated to tsinghua university as the leader of the unit, great feats as clinical research of bidders, and rui was born joint PPI (proton pump inhibitors) in the treatment of Endoscopic submucosal dissection surgery, Endoscopic submucosal dissection, ESD) after artificial ulcer clinical trial scheme discussion meeting in crowne plaza Beijing lido 22nd floor conference room is held ceremoniously. This clinical study is planned to be carried out in 10 authoritative centers in the field of digestive endoscopy in China, with a total of 200 enrolled subjects.

The meeting around the experimental study on the scheme, the ESD postoperative artificial ulcer related issues for further discussion, in order to further verify the red was born with esso beauty pull azole therapy ESD postoperative efficacy and safety of the ulcer of multi-center clinical research work laid the foundation of project startup, at the same time, also further promote the explore the optimal scheme of the ESD postoperative gastric ulcer drugs and treatment, and for our ESD ulcer after drug treatment to provide more evidence of evidence-based medicine (ebm), the meeting successfully.

Professor Jiang Bo, chairman of the clinical trial program discussion conference, delivered a speech. With the development and extensive application of endoscopy, the detection rate of early gastrointestinal tumors has been greatly improved, he said. A large number of studies have shown that endoscopic therapy can achieve the same effect as surgical treatment in patients with early gastrointestinal tumors. ESD has the advantages of small trauma, quick postoperative recovery, and residual lesions, recurrence rare. However, the treatment and management of artificial ulcers with a wide range of lesions after dissection cannot be ignored. A large number of studies believe that PPI combined with mucosal protective agent can obtain significant synergistic effect, but the heterogeneity of the current studies is relatively large. Therefore, the best treatment for artificial ulcer after ESD operation is still controversial. How to improve the healing quality of postoperative artificial ulcers and reduce postoperative complications is the main factor affecting the prognosis of patients, and it is also the responsibility and challenge of clinical endoscopists, which is the original intention and significance of this clinical study.

Mr. Xie Wenbo, the general manager, introduced the general situation of Great Career company, the clinical research initiated and completed by Rayleigh, and the product positioning and research direction in the future.

Professor Du Shiyu of Beijing China-Japan Friendship Hospital interpreted the guidelines for perioperative Period of gastric endoscopy submucosal dissection, and made a speech in academic exchange on medication management after ESD operation. According to Du, iatrogenic ulcers are inevitable after ESD surgery, leading to many adverse events such as pain, bleeding and perforation. Persistent ulceration in ESD recipients results in a risk of delayed bleeding and persistent upper abdominal pain. Therefore, it should be paid enough attention to the treatment of iatrogenic ulcer caused by ESD, drug management is particularly important, and a meta-analysis shows that THE ulcer healing rate of PPI combined with gastric mucosal protective agent after ESD is significantly higher than that of PPI alone. Many authoritative guidelines at home and abroad have made clear the therapeutic value and status of mucosal protective agent.

Jilin city people's hospital professor ullrich around the pathophysiological process of wound repair and ulcer healing factors, etc., this paper expounds the poly pury zinc as L - carnosine and zinc chelate in promoting healing mechanisms, including stimulate mucin secretion, anti-oxidation, the stability of cell membrane, induction of heat shock protein (HSP) and heme oxygenase (HO) and so on. He also combined with the typical cases of the hospital, the clinical research of the basis and research prospects are confirmed.

Participating experts speak freely and share the gluttonous feast of academic thought collision. The meeting profoundly analyzed the current problems and challenges in the management of artificial ulcer medication after ESD operation, and analyzed the benefits of mucosal protective agents from multiple perspectives, providing new ideas for the treatment of artificial ulcers after ESD operation.

Finally, all the experts on the focus of the issues involved in this clinical trial, including the test drug acquisition and management, dosage regimen, disease diagnostic criteria, curative effect, test group, all criteria to primary and secondary indicators of collection, the measurement and evaluation of curative effect, as well as the quantitative classification standard and other key issues for further discussion. Ms. Li Mingru, the representative of the sponsor, made a detailed record of the above problems according to the Suggestions of experts and improved the research scheme. After the meeting, Ms. Li Mingru consulted professor Zhang Xiaofei, an authoritative expert in clinical epidemiology and biostatistics, on the statistical issues involved in this research plan.

Research plan of the conference on clinical test, ESD postoperative artificial ulcer related question has carried on the thorough discussion, in order to further verify the red was born with esso beauty pull azole therapy ESD postoperative efficacy and safety of the ulcer of multi-center clinical research project start work laid a solid foundation, at the same time, also further promote the population of our country the ESD postoperative gastric ulcer drug treatment, the optimal scheme and the course of exploration.

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