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Prevent esophageal stricture-Polyprezinc particles

Prevent esophageal stricture-Polyprezinc particles

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-12-03
  • Views:0

(Summary description)

Prevent esophageal stricture-Polyprezinc particles

(Summary description)

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-12-03
  • Views:0
Information

  Accidental inhalation of corrosive substances, causing corrosive damage is a worldwide urgent problem in pediatrics. Excessive intake of alkaline substances can cause liquefaction and necrosis of the esophagus, and penetration into the esophagus can cause severe esophageal stricture. Esophageal stricture is the most worrying complication in children, with an incidence of 2%-63%. It is very difficult to treat esophageal stenosis, and various stents are needed to expand the esophagus. Treatment of corrosive esophageal burns (CEB) can prevent or reduce the formation of esophageal strictures. Currently, clinical medications include steroids and mitomycin C. Polyprezinc is a chelate composed of zinc ions and L-carnosine. It is clinically used to treat gastric ulcers. Studies have shown that it has anti-inflammatory, anti-oxidant, anti-fibrotic, and protective and repair mucosal damage effects. Based on the above, let's explore the effectiveness of polyprezinc in preventing esophageal stenosis after burns.

  Materials and Method

  1.1 Animal grouping

  24 Wistar albino rats, weighing 222-273g, were randomly divided into 4 groups with 6 rats in each group. Control group (group C): rats do not receive CEB and any treatment; esophageal burn group (group B): rats are given experimental CEB, but no treatment; low-dose group (PT1 group) and high-dose group (PT2 group) ): Rats were given experimental CEB and polyprezinc (PT1100mg/kg and PT2200mg/kg) for 2 weeks, and then the same dose of polyprezinc was orally administered for 2 weeks; the intra-abdominal esophagus segment was removed 4 weeks later.

  1.2 Model establishment 12h fasting with water before modeling, anesthetized with ketamine hydrochloride (45mg/kg), and intramuscular injection. The 2cm abdominal segment of the esophagus was isolated and an experimental CEB model was successfully established. The samples were stored in liquid nitrogen and 10% formaldehyde solution for detection of HP levels and histopathological observation.

  1.3 Histopathology

  sections were stained with hematoxylin and Masson three-color connective tissue to determine collagen deposition. Semi-quantitative evaluation of esophageal collagen deposition and score of the severity of corrosive esophageal burns in rats. The increase of submucosal collagen is calculated as none (0), mild (submucosal collagen is at least twice the thickness of the muscularis mucosa; 1+), and severe (submucosal collagen exceeds twice the thickness of the muscularis mucosa; 2+); Muscle mucosal injury is calculated as none (0) or presence (1+); muscle layer injury and collagen deposition are calculated as none (0), mild (collagen is deposited around smooth muscle fibers; 1+), severe (same as mild, Collagen deposition replaces some muscle fibers; 2+);

  Healthy esophageal cavity is easy to dilate. Wound contraction promotes the healing of corrosive injuries, which corresponds to the formation of stricture during corrosive burns of the esophagus. In corrosive esophageal injury, the density of the tube wall increases and the tube diameter decreases. Therefore, the lumen of the corrosive esophagus is narrow and difficult to expand. In addition to the esophageal space, the thickness of the esophageal wall is also an important indicator for calculating SI, the stenosis index (SI): stenosis index = wall thickness / lumen diameter.

  1.4 Hydroxyproline (HP) determination

  Using Woessner technology to measure tissue HP level, expressed in μg/mg tissue.

  结 果

  2.1 The effect of polyprezinc on the body weight of rats

  As shown in Table 1, the weight of group C increased, and the weight of group B after corrosive esophageal burns was significantly reduced. After polyprezine treatment, the weight of PT1 group decreased slightly, and the weight of PT2 group increased, indicating that polyprezinc can effectively maintain corrosion Severe esophagus burns the weight of rats.

  2.2 The effect of polyprezinc on the level of HP in rats

  As shown in Table 2, the HP level of the normal group C was the lowest, and the HP level of the group B after corrosive esophageal burns was significantly increased. After treatment with polyprezinc, the HP level in the rats was effectively reduced.

  2.3 The effect of polyprezinc on the stenosis index (SI) of rats

  As shown in Table 2, compared with group C, the stenosis index of group B rats after corrosive esophageal burns was significantly increased, indicating that the esophageal burn model was successfully established (Figures 4 and 5). Compared with group B and PT1 and PT2, polyprezinc treatment significantly reduced the stenosis index, and the difference was significant.

  2.4 The effect of polyprezinc on histopathological damage score in rats

  There is no fibrosis in group C, and the histopathological damage score of group B after corrosive esophageal burns is the highest, with significant differences, which also shows that the CEB model was successfully established. After polyprezinc treatment, the injury scores of the PT1 and PT2 groups were significantly reduced.

  Discuss   Discuss

  Polyprezinc can effectively reduce the formation of esophageal stenosis after esophageal burns, thereby reducing the risk of esophageal stenosis by maintaining the weight of rats, reducing the level of HP, stenosis index and histopathological damage scores in rats. Therefore, polyprene zinc particles can be used as an effective drug to prevent the formation of esophageal stricture.

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