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Why did the deyou fail? Relaisson will help you solve the "you"!

Why did the deyou fail? Relaisson will help you solve the "you"!

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-12-01
  • Views:0

(Summary description)

Why did the deyou fail? Relaisson will help you solve the "you"!

(Summary description)

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-12-01
  • Views:0
Information

 

 ——Biological characteristics of Helicobacter pylori

  In the treatment of Helicobacter pylori (Hp), it is often found that there are a large number of spherical Hp in the pathological tissue of the gastric mucosa in patients with chronic gastritis treated with antibiotics. Studies have found that this spherical Hp is not sensitive to antibiotic treatment, that is, in the non-response period. Therefore, the spherical change of Hp is considered to be one of the reasons for the failure of Hp treatment.

  At present, it is believed that spherically transformed Hp mainly exists in two forms: one is dead or denatured Hp; the other is Hp that is not dead but cannot be cultured in the inactive period. When the growth environment is poor, such as increased oxygen tension, alkaline environment, temperature increase or antibiotic intervention can cause spherical change. It has been proven to be tolerant to physical and chemical factors for at least 30 days, and under suitable conditions, it takes 4-6 weeks to grow again and return to propagule state. Although Hp spheroids cannot be cultured, some experiments suggest that this form is still viable and infectious. However, some studies believe that the spherical transformation is the morphological feature of bacterial death, and the spherical transformation of Hp that has nothing to do with external factors has been observed, accompanied by changes in the ultrastructure and antigenic characteristics, such as:

  ✔ The quantity and integrity of RNA and DNA are significantly reduced;

  ✔ Membrane protein reduction;

  The inhibitory effect of antibiotics on RNA and protein synthesis cannot promote the occurrence of spherical transformation, but it can increase the spherical transformation rate of bacteria. Therefore, Hp spherical transformation may be a passive process, without the involvement of protein synthesis process.

  Therefore, the spherical change in clinical treatment is of special significance to the failure of Hp treatment. The metabolic activity of the spherical change of Hp is relatively low, and the urease activity is reduced, so the sensitivity to antibiotics is reduced.

  Antibiotics have a killing effect on Hp in the active growth period, but have no killing effect on Hp in the inactive period, such as spherical change.

  Therefore, if H. pylori eradication treatment fails, H. pylori remedial treatment is recommended, and an interval of 2-3 months is recommended (the fifth national consensus report on the treatment of Hp infection).

  During these 2 to 3 months, only when the bacteria are allowed to grow happily and recover from the spherical body to the propagule state, will they respond to antibiotics and the treatment will be valuable. During this period, you can take some mucosal protective drugs, such as polyprezinc.

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