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Xiao Rui talks about popular science|The grievances between aspirin and thrombus

Xiao Rui talks about popular science|The grievances between aspirin and thrombus

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-11-18
  • Views:0

(Summary description)

Xiao Rui talks about popular science|The grievances between aspirin and thrombus

(Summary description)

  • Categories:Stomach healthy
  • Author:
  • Origin:
  • Time of issue:2020-11-18
  • Views:0
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  Let me talk about the origin of the grievances between them    In the 1980s, scientists discovered that aspirin can inhibit platelet aggregation, making aspirin a famous antiplatelet drug. Many middle-aged and elderly people regard it as a "life-saving pill" to prevent thrombosis and stay away from cardiovascular and cerebrovascular infarctions, but the side effects of aspirin on the gastrointestinal tract have also brought people a lot of trouble.   Although troubles continue, it is inseparable! How to find a balance between bleeding and thrombosis is really a nerve-wracking problem, and it is also the so-called "graciousness". At present, most of the enteric-coated aspirin tablets can greatly reduce the risk of gastrointestinal bleeding, but are you really getting a series of problems such as the way of taking and dosage? Now Xiao Rui will explain to you aspirin from this aspect. How to eat? You also ask yourself "Did I eat right?"    It is better to take in the morning than at night    The adverse reaction of aspirin is mainly manifested as gastrointestinal discomfort; studies have shown that the incidence of adverse reactions in the morning is significantly lower than that in the evening. Some scholars believe that the body's vagus nerve is more excited at night, and the secretion of gastric juice is stronger. If aspirin is taken at night, it may increase the adverse reactions of the digestive tract. Therefore, taking aspirin in the morning in patients with coronary heart disease can strengthen its effect of inhibiting platelet aggregation and help reduce the occurrence of adverse gastrointestinal reactions.    From the perspective of the body's biological clock, from 6 am to 10 am, blood viscosity, blood pressure and heart rate levels are high, which is the time when cardiovascular and cerebrovascular diseases occur frequently. Therefore, in order to achieve the purpose of preventing and treating cardiovascular and cerebrovascular diseases, taking aspirin from 7 am to 8 am has the best effect.    It is better to take before meals than after meals    The traditional use of aspirin preparations is to take them after meals, the purpose is to reduce the direct damage to the gastrointestinal mucosa. The outer bread of aspirin enteric-coated tablets has an enteric-coated film, which can resist the acidic environment in the stomach, and can only be decomposed in the alkaline environment in the duodenum, thereby avoiding damage to the gastric mucosa. If taken after a meal, the food relieves the acidic environment in the stomach, the acidity of the gastric juice increases, and the medicine is easily dissolved.   The mixing of medicine and food will extend the residence time of the medicine in the stomach. It will also cause damage to the enteric membrane and increase the chance of the medicine being dissolved in the stomach. Taking aspirin enteric-coated tablets before meals can reduce the damage to gastric mucosa due to the strong acidic environment in the fasting state, the drug is not easy to dissolve, and the gastric emptying speed is fast after taking it on an empty stomach, and the residence time in the stomach is short. Therefore, the effect of taking aspirin enteric-coated tablets before meals is better.    Take care about the dosage The antithrombotic function of low-dose aspirin is mainly due to its "platelet inhibition" effect. Studies have shown that 75-100mg aspirin has the best antithrombotic effect and the smallest incidence of bleeding; however, after increasing the dose, the effect does not increase. Bleeding incidents have obviously increased. Therefore, long-term, low-dose aspirin is recommended, and enteric-coated preparations are best.    Specific groups need to be cautious   Several situations and groups of people who need to be cautious about taking aspirin, and whether it is necessary to take it specifically, require a comprehensive judgment and selection by the doctor based on the clinical risks and benefits.   1). 1 week before the operation;    2). After drinking;   3). Pregnant women and those with severe liver insufficiency;   4). Those with bleeding tendency, bleeding disorders, or low platelets;   5). Patients with peptic ulcer and reflux esophagitis;   6). Asthma patients and aspirin allergy;   7). Those who are taking vitamin B1, certain hypoglycemic drugs and other anticoagulants (warfarin).

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