Jilin Province Great Great Pharmaceutical Co. LTD

Jilin Province Broadwell Pharmaceutical Co., LTD. Welcome you!

Service hotline:+86-431-85639055

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Jilin Province Great Great Pharmaceutical Co. LTD

Jilin Broadwell Pharmaceutical Co., Ltd. is a biochemical pharmaceutical limited company founded in April, 2010, which takes maintaining the human health as the philosophy, takes widely collecting scientific essence, and creating permanent undertaking as core values, and adopts a sustainable development strategy depending on two R&D platforms of biological and chemical drugs. The company concentrates on biochemical pharmaceuticals, and focuses on the market layout of R&D, production and sales of cardiovascular, cerebrovascular and digestive drugs. - The chemical drugs R&D platform, adopts a follower strategy, introduces the first generic or quick generic drugs of foreign expired and expiring patent medicines, and launches them in the domestic market.

 

 

  • 2010

    years

    Great Greatness was formally founded

  • 9700

    Ten thousand yuan

    Registered capital

  • 30+

    a

    New drugs in development

PRODUCT

CENTER

Jilin Province Great Great Pharmaceutical Co. LTD
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Broad Great Pharma

Maintain the health of the people


Polaprezine

Polaprezine is a complex compound formed by zinc and L-carnosine. Zinc is an ideal carrier for L-carnosine. The two produce a significant synergy.

Sodium Ferulate

Sodium ferulate is the sodium salt of ferulic acid, which is the main component of angelica sinensis, a traditional Chinese medicine for promoting blood circulation to remove blood stasis. The sodium ferulate injection compounded by using modern technology, not only retains the effect of promoting blood circulation to remove blood stasis of angelica sinensis, but gives a new connotation. The endothelin receptor antagonists are oxidation resistant, which can clear free radicals, and prevent platelet aggregation, with anti-inflammatory and immune adjustments, increasing blood creation function.

Neuropsychiatric Products

XY-AG: Originally developed by French Servier., it is the exclusive first generic product in China, and an antidepressant drug, which is a new breakthrough in the field of depression treatment (this variety has been declared to the SFDA for review). XY-TBZ: Originally developed by Janssen Pharmaceutical Ltd., it is a domestic clinical blockbuster drug for the treatment of epilepsy and migraine, with a unique mechanism of action.

Propyl Gallate

This product is a medicine with a stronger biological effect obtained by structural modification of the main active component - propyl gallate, on the basis of in-depth study of paeoniae radix rubra, a traditional Chinese medicine used for promoting blood circulation to remove blood stasis. This product can significantly inhibit platelet aggregation; enhance fibrinolytic activity, promote thrombolysis; reduce whole blood viscosity and plasma specific viscosity;

Anti-infection Products

XY-LN: Originally developed by Pfizer, it is the only drug for the treatment of vancomycin infection, which fills the gap in the few drugs that solve the clinical drug resistance problem (this variety has been declared to the SFDA for review).

Atrial Vessel Products

Innovation System R&D Capability Products under Research Scientific Research Cooperation

R&D

INNOVATION

Jilin Province Great Great Pharmaceutical Co. LTD
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Jilin Province Great Great Pharmaceutical Co. LTD

HEALTH

SCIENCE

Jilin Province Great Great Pharmaceutical Co. LTD
Rayleigh - A face - to - face view of Poly Prion zinc granules
Rayleigh



L-carinosin zinc complex (L-CAZ), also known as Polaprezinc, is the first oral medication with zinc as its main ingredient, clinically used to treat stomach ulcers. Due to the polymerization characteristic of L-CAZ, it can be slowly dissociated in gastric juice and function for a long time, and adhere to the ulcer focus specifically, releasing L-carnosine and zinc to treat ulcers. The clinical application effect of polyprezon was good and no serious adverse reactions occurred. At the same time, the growth of Hp was significantly inhibited by polyprazine.

Why is the combination of zinc and L-carnosine optimal?

1. L-carnosine is one of the most ideal ligands for zinc

L-carnosine is composed of -alanine (Ala) and L-histidine (His). Table 1 shows the main chemical forms of zinc in human plasma, clearly indicating the importance of histidine in zinc complexation. Therefore, L-carnosine is considered as one of the most ideal ligand for zinc, which can be used in the medical field.

Table 1 Main chemical forms and distribution of trace element complexes in human model plasma



2. L-carnosine is the ideal transporter of zinc

We studied the therapeutic effect of polypretidine and other zinc compounds on gastric ulcer, and the results showed that the anti-ulcer effect of polypretidine was significantly better than that of cimetidine at the same dose (Table 2). Cimetidine is a recognized drug for gastric ulcer.

Table 2 Inhibitory effects of zinc compound on gastric ulcer stress in rats after immersion in water



How does polyprion zinc play a role?

Poly pury zinc to specific adhesion of ulcer lesions from zinc and form new chemical bonds between human body composition, the human body composition/other proteins (albumin) in the ulcer site seepage, and has the functional groups such as sulphur or imidazole, forming complexes of zinc ions firmly with the L - carnosine and zinc is still in a state of combination, so the ulcer local play a role of exogenous protection. During complex formation, a small amount of carnosinin is released in the ulcer and replaces the human body components, playing a role of local anti-inflammation and anti-oxidation, while zinc will accumulate in the ulcer and form a larger zinc complex, capturing human components and entering the ulcer to relieve inflammation.

Studies have shown that gastric mucosal protective effect of zinc pury and do not rely on dmPGE ₂, at the same time also has anti-inflammatory antioxidant, promoting wound healing, membrane stability, cell protection and promote mucosal defense mechanism, and so on, for all kinds of experimental ulcer model has very good therapeutic effect, so can act as endogenous repair function.

Can Polypramide inhibit Hp growth? Is it toxic?

The eradication rate of Hp was significantly improved by Rayleixen (Polyprazine)

In recent years, the eradication of Helicobacter pylori (Hp) has attracted much attention. Drugs that can improve the eradication rate of Hp are of great significance. Rui was born (poly pury zinc particles) Ⅳ phase of clinical trial results show that the red was born combined triple therapy of Hp eradicate rate is significantly higher than that of conventional triple therapy, Hp eradicate rate increased by 19.7% (figure 1), and no difference between the incidence of adverse reactions.



  

Figure 1 Helicobacter pylori eradication rates in ITT and PP populations

Arm A: Relicin 75mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice A day; Arm B: Relicin 150mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice a day; Arm C: Omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500m, oral twice a day.

Many clinical studies have shown significant improvement in symptoms and compliance in patients treated with polypramide for ulcers. The cure rate of endoscopic ulcer was 27.3% and 64.5% after 4 and 8 weeks of treatment, respectively. After 4 weeks and 8 weeks, the "significant improvement" rate was 61.3% and 72.0%, respectively. No adverse reactions were reported in 691 clinical trials, indicating that polypramide is safe and non-toxic.

Can polyprede zinc take for a long time? Is there any accumulation?

Using 14C to mark the carnosine in polypramide, urine containing 4.1%, feces containing 13.3%, 38% in the form of gas, it can be seen that carnosine is mainly discharged from the body in the form of gas;

65Zn was used to mark the zinc ions in poly Prion zinc, urine containing 0.3%, indicating that zinc basically does not pass the excretion of the kidney, for renal insufficiency can also take normally, stool containing 85.0%, absorbed about 11%, which indicates that zinc ions in the body is safe without accumulation, can be taken for a long time.

Have discussions

Helicobacter pylori (Hp) bacteria in the body contains a lot of urea enzyme activity, it is an important pathogenic factors of Hp infection, a large number of studies have shown that poly pury zinc Hp eradication of pharmacologic



L-carinosin zinc complex (L-CAZ), also known as Polaprezinc, is the first oral medication with zinc as its main ingredient, clinically used to treat stomach ulcers. Due to the polymerization characteristic of L-CAZ, it can be slowly dissociated in gastric juice and function for a long time, and adhere to the ulcer focus specifically, releasing L-carnosine and zinc to treat ulcers. The clinical application effect of polyprezon was good and no serious adverse reactions occurred. At the same time, the growth of Hp was significantly inhibited by polyprazine.

Why is the combination of zinc and L-carnosine optimal?

1. L-carnosine is one of the most ideal ligands for zinc

L-carnosine is composed of -alanine (Ala) and L-histidine (His). Table 1 shows the main chemical forms of zinc in human plasma, clearly indicating the importance of histidine in zinc complexation. Therefore, L-carnosine is considered as one of the most ideal ligand for zinc, which can be used in the medical field.

Table 1 Main chemical forms and distribution of trace element complexes in human model plasma



2. L-carnosine is the ideal transporter of zinc

We studied the therapeutic effect of polypretidine and other zinc compounds on gastric ulcer, and the results showed that the anti-ulcer effect of polypretidine was significantly better than that of cimetidine at the same dose (Table 2). Cimetidine is a recognized drug for gastric ulcer.

Table 2 Inhibitory effects of zinc compound on gastric ulcer stress in rats after immersion in water



How does polyprion zinc play a role?

Poly pury zinc to specific adhesion of ulcer lesions from zinc and form new chemical bonds between human body composition, the human body composition/other proteins (albumin) in the ulcer site seepage, and has the functional groups such as sulphur or imidazole, forming complexes of zinc ions firmly with the L - carnosine and zinc is still in a state of combination, so the ulcer local play a role of exogenous protection. During complex formation, a small amount of carnosinin is released in the ulcer and replaces the human body components, playing a role of local anti-inflammation and anti-oxidation, while zinc will accumulate in the ulcer and form a larger zinc complex, capturing human components and entering the ulcer to relieve inflammation.

Studies have shown that gastric mucosal protective effect of zinc pury and do not rely on dmPGE ₂, at the same time also has anti-inflammatory antioxidant, promoting wound healing, membrane stability, cell protection and promote mucosal defense mechanism, and so on, for all kinds of experimental ulcer model has very good therapeutic effect, so can act as endogenous repair function.

Can Polypramide inhibit Hp growth? Is it toxic?

The eradication rate of Hp was significantly improved by Rayleixen (Polyprazine)

In recent years, the eradication of Helicobacter pylori (Hp) has attracted much attention. Drugs that can improve the eradication rate of Hp are of great significance. Rui was born (poly pury zinc particles) Ⅳ phase of clinical trial results show that the red was born combined triple therapy of Hp eradicate rate is significantly higher than that of conventional triple therapy, Hp eradicate rate increased by 19.7% (figure 1), and no difference between the incidence of adverse reactions.



  

Figure 1 Helicobacter pylori eradication rates in ITT and PP populations

Arm A: Relicin 75mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice A day; Arm B: Relicin 150mg+ omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500mg, oral twice a day; Arm C: Omeprazole 20mg+ amoxicillin 1g+ clarithromycin 500m, oral twice a day.

Many clinical studies have shown significant improvement in symptoms and compliance in patients treated with polypramide for ulcers. The cure rate of endoscopic ulcer was 27.3% and 64.5% after 4 and 8 weeks of treatment, respectively. After 4 weeks and 8 weeks, the "significant improvement" rate was 61.3% and 72.0%, respectively. No adverse reactions were reported in 691 clinical trials, indicating that polypramide is safe and non-toxic.

Can polyprede zinc take for a long time? Is there any accumulation?

Using 14C to mark the carnosine in polypramide, urine containing 4.1%, feces containing 13.3%, 38% in the form of gas, it can be seen that carnosine is mainly discharged from the body in the form of gas;

65Zn was used to mark the zinc ions in poly Prion zinc, urine containing 0.3%, indicating that zinc basically does not pass the excretion of the kidney, for renal insufficiency can also take normally, stool containing 85.0%, absorbed about 11%, which indicates that zinc ions in the body is safe without accumulation, can be taken for a long time.

Have discussions

Helicobacter pylori (Hp) bacteria in the body contains a lot of urea enzyme activity, it is an important pathogenic factors of Hp infection, a large number of studies have shown that poly pury zinc Hp eradication of pharmacologic
瑞莱生|聚普瑞锌颗粒
瑞莱生|聚普瑞锌颗粒
聚普瑞锌颗粒是锌与L-肌肽的螯合剂型,于1994年在日本首次上市(商品名为Promac)。吉林省博大伟业制药有限公司对其进行首仿,并于2012年成功获批上市。根据国外上市25年相关研究资料显示,聚普瑞锌得到近千万黏膜损伤性相关疾病患者的肯定;同时,国外相关研究机构开展了近百项试验(实验)研究,对其有效性与安全性进行进一步验证。
聚普瑞锌颗粒是锌与L-肌肽的螯合剂型,于1994年在日本首次上市(商品名为Promac)。吉林省博大伟业制药有限公司对其进行首仿,并于2012年成功获批上市。根据国外上市25年相关研究资料显示,聚普瑞锌得到近千万黏膜损伤性相关疾病患者的肯定;同时,国外相关研究机构开展了近百项试验(实验)研究,对其有效性与安全性进行进一步验证。
When carnosine meets zinc
When


The story takes place on April 13, 1994. In a European-style gallery in Japan, the classic works of artists are on display. The whole exhibition hall is full of classical colors. The bronzed wallpaper and walnut floor set off each other. Under the light of the crystal chandelier like flickering by candlelight, it gives out a strong sense of era, which also adds a hint of mystery to the whole gallery.

Hollywood actor Shrek accompanied his beloved princess to the exhibition, where they stood for a long time in front of a classic painting.

Green, rough-looking and with a kind heart, Shrek is gripped by the book's title and pondered for a long time.

Shrek looked carefully at the introduction, Riley, and there was a line below that read: when carnosine meets zinc.

Shrek and the princess set off on a journey of discovery...



 

Hello!

I am a member of great Greatness's family,

Rui lai,

General name: Polyprezon,

English name: Polaprezinc








The story takes place on April 13, 1994. In a European-style gallery in Japan, the classic works of artists are on display. The whole exhibition hall is full of classical colors. The bronzed wallpaper and walnut floor set off each other. Under the light of the crystal chandelier like flickering by candlelight, it gives out a strong sense of era, which also adds a hint of mystery to the whole gallery.

Hollywood actor Shrek accompanied his beloved princess to the exhibition, where they stood for a long time in front of a classic painting.

Green, rough-looking and with a kind heart, Shrek is gripped by the book's title and pondered for a long time.

Shrek looked carefully at the introduction, Riley, and there was a line below that read: when carnosine meets zinc.

Shrek and the princess set off on a journey of discovery...



 

Hello!

I am a member of great Greatness's family,

Rui lai,

General name: Polyprezon,

English name: Polaprezinc






NEWS

CENTER

Jilin Province Great Great Pharmaceutical Co. LTD
Fraternity Club" -- To demonstrate corporate mission and responsibility in the face of the epidemic
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Chai Wei, secretary of CPC Municipal Committee, visited our company to investigate the promotion of liaoyuan "Sika deer + medical and health industry"
With a deep concern for the liaoyuan medical and health industry, with the city of Liaoyuan "Sika deer + medical and health industry" a bright future. On the afternoon of September 16, more than 30 people, including Party secretary Chai Wei, Leaders Such as CAI Hongwei, Hu Yongwei, Tang Yan, Xu Hui, Chen Zhongliang and Zhang Fenglin, visited Broad Enterprise for investigation. Duan Chengjun, chairman of the board, introduced to the city leaders the development of our company in the past ten years, new product research and development, marketing and sales, platform construction, and the promotion of the "Sika deer + medical and health industry" work. In the past two years, our company has actively negotiated with the government of The Development zone and The Government of Liaoyuan city, negotiated with the academician workstation, adopted the government's promotion, academician's substantial participation, implemented the enterprise management, marketized operation mode, committed to the research and development and production of Sika deer products, and established Jilin Province Glast Biotechnology Co., LTD. The company has signed a cooperation agreement with academician workstation, and developed and produced series products such as deer antler health care products and food products by utilizing its technical resources, technical team and innovation achievements and relying on broad Cause's pilot test ability and industrial advantages.      Secretary wood to great achievements as the President unit of the medicine industry of jilin province technology innovation strategic alliance, promote union work and to undertake manufacture-learning-research cooperation with enterprise as the main body, the company has strong research and development ability and innovation ability to be fully recognized and high hopes and great play a leading role in industry, for Ming "sika deer + medicine health industry" stable healthy development contribution strength, instructs the staff service. Relevant leaders from the municipal Commission office, the Government office, the Political Research Office, the Development and Reform Commission, the Bureau of Science and Technology, the Bureau of Industry and Information Technology, the Bureau of Ecology and Environment, the Bureau of Commerce, the Federation of Industry and Commerce, the Tax bureau, the Bureau of Statistics, and the administrative Committee of the Development Zone accompanied the investigation.
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The deputy director of the Provincial Department of Industry and Information Technology Mu Kezhen and his leaders came to our company for investigation
Braving the 35-degree heat and the coming heat wave, on the afternoon of July 23, mu Kezhen, deputy director of The Industry and Information Technology Department of The Province, Ma Guang, director of consumer goods Department of the Industry and Information Technology Department of the Province, Zhang Yinghong, director of the medical Department of the Industry and Information Technology Department of the Province and more than 10 people came to our company to investigate the production operation. Wu Shaohui, executive deputy general manager, introduced the development history and current production operation of our company in detail to the research group and answered their questions from time to time. The research group appreciated the achievements of our company in the past 10 years in the development, production and sales of cardiovascular and cerebrovascular, digestive, anti-cancer, neuropsychiatric drugs, which has been committed to the cause of human health and focused on biochemical pharmaceutical. Vice Director Mu Kezhen pointed out that in order to overcome the adverse impact of the epidemic, strengthen confidence in development, accurately grasp the new situation and new trends in the industry, enterprises should constantly strengthen their own technological transformation and innovation, and enhance their core competitiveness. All departments of the Provincial Department of Industry and Information Technology will earnestly enhance the sense of service, follow the front service, take the initiative, increase the support for enterprises from policy, technology, capital, talent and other aspects, create good conditions for the development of enterprises, promote the implementation of all policies to be detailed, and protect the healthy and rapid development of enterprises. Vice Mayor Xu Hui, Deputy secretary General Chen Zhongliang of the municipal Government, Director Zhu Yongku of the Municipal Industry and Information Technology Bureau and other officials accompanied the investigation.
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Provincial drug administration service "two products and one device" enterprise development symposium was held in our company
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Vice Mayor Xu Hui visited Changchun Pharmaceutical Research Institute of Great Undertaking for investigation
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Cooperate with provincial institute for mutual benefit and win-win to jointly promote the high-quality development of the pharmaceutical and health industry of Jilin Province
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Jilin Province Great Great Pharmaceutical Co. LTD

Service hotline

+86-431-81158731

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Jilin Province Great Great Pharmaceutical Co. LTD

Jilin Province Great Great Pharmaceutical Co. LTD
Jilin Province Great Great Pharmaceutical Co. LTD
Jilin Province Great Great Pharmaceutical Co. LTD
Jilin Province Great Great Pharmaceutical Co. LTD
Jilin Province Great Great Pharmaceutical Co. LTD
Jilin Province Great Great Pharmaceutical Co. LTD

Liaoyuan Production Base: No. 158 Fortune Road, Liaoyuan Economic Development Zone, Jilin Province

Tel:+86-437-6998023

Changchun R&D Center: No. 3786 Juye Street, Jingyue Development Zone, Changchun City, Jilin Province
Tel:+86-431-81158731(Marketing center)

Tel:+86-431-81158756(Research and development center)

Beijing Office: Room 901, Building F, Kaixuan City, 170 Beiyuan Road, Chaoyang District, Beijing
Tel:+86-10-58236233

Medication consultation, feedback on medication adverse reaction, and user complaint telephone:0437-5029815 

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